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. 2024 Mar 21;52(10):5529–5548. doi: 10.1093/nar/gkae183

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Models for the functional outcomes of H3K18la modification in the early reprogramming. Dux facilitated iPSCs reprogramming by enhancing the level of H3K18la modification, a process regulated by OGS and histone modification enzymes. Brg1, acting as a reader in the regulatory network, recognized lactylated histone H3. The combination of H3K18la and Brg1 accumulated on the promoters of genes related to pluripotency and epithelial function, thereby promoting the process of cellular MET. The regulation of H3K18la during the early stages of reprogramming ultimately impacted the efficiency of iPSCs reprogramming.