Table 1.
Univariate and multivariate Cox regression analyses of main characteristics.
| Characteristic | Overall | Univariate Cox | Multivariate Cox | ||||
|---|---|---|---|---|---|---|---|
| N = 2197a | HRb | 95% CIb | p-value | HRb | 95% CIb | p-value | |
| Age | < 0.001 | < 0.001 | |||||
| ≤ 66 | 1548 (70%) | – | – | – | – | ||
| > 66, ≤ 77 | 505 (23%) | 1.32 | 1.16, 1.49 | 1.22 | 1.07, 1.39 | ||
| > 77 | 144 (6.6%) | 2.23 | 1.85, 2.69 | 1.67 | 1.37, 2.04 | ||
| Race | < 0.001 | 0.082 | |||||
| American Indian/Alaska Native | 36 (1.6%) | – | – | – | – | ||
| Asian or Pacific Islander | 478 (22%) | 0.71 | 0.47, 1.08 | 1.36 | 0.88, 2.10 | ||
| Black | 228 (10%) | 1.05 | 0.68, 1.62 | 1.64 | 1.05, 2.56 | ||
| White | 1455 (66%) | 0.91 | 0.61, 1.36 | 1.47 | 0.97, 2.24 | ||
| Marital_status | < 0.001 | < 0.001 | |||||
| Married | 1319 (60%) | – | – | – | – | ||
| Other | 878 (40%) | 1.38 | 1.24, 1.54 | 1.27 | 1.13, 1.42 | ||
| Histological_type | < 0.001 | 0.002 | |||||
| 8170 | 2154 (98%) | – | – | – | – | ||
| 8171 | 2 (< 0.1%) | 1.94 | 0.49, 7.78 | 3.26 | 0.79, 13.5 | ||
| 8172 | 3 (0.1%) | 0.00 | 0.00, Inf | 0.00 | 0.00, Inf | ||
| 8173 | 3 (0.1%) | 27.5 | 8.77, 86.3 | 7.91 | 2.46, 25.5 | ||
| 8174 | 34 (1.5%) | 1.25 | 0.84, 1.88 | 1.55 | 1.02, 2.35 | ||
| 8175 | 1 (< 0.1%) | 4.97 | 0.70, 35.4 | 6.37 | 0.88, 46.1 | ||
| Grade | < 0.001 | < 0.001 | |||||
| Moderately differentiated; Grade II | 1104 (50%) | – | – | – | – | ||
| Poorly differentiated; Grade III | 402 (18%) | 1.55 | 1.35, 1.79 | 1.32 | 1.14, 1.54 | ||
| Undifferentiated; anaplastic; Grade IV | 22 (1.0%) | 1.86 | 1.17, 2.98 | 1.36 | 0.84, 2.19 | ||
| Well differentiated; Grade I | 669 (30%) | 0.95 | 0.84, 1.08 | 0.81 | 0.71, 0.92 | ||
| Stage | < 0.001 | < 0.001 | |||||
| I | 1054 (48%) | – | – | – | – | ||
| II | 642 (29%) | 1.23 | 1.08, 1.41 | 1.53 | 0.85, 2.73 | ||
| III | 344 (16%) | 3.26 | 2.83, 3.77 | 2.20 | 1.34, 3.61 | ||
| IV | 157 (7.1%) | 5.59 | 4.64, 6.74 | 3.33 | 1.79, 6.16 | ||
| T | < 0.001 | < 0.001 | |||||
| T1 | 1079 (49%) | – | – | – | – | ||
| T2 | 677 (31%) | 1.25 | 1.10, 1.43 | 0.85 | 0.49, 1.50 | ||
| T3a | 260 (12%) | 2.98 | 2.54, 3.49 | 0.79 | 0.48, 1.28 | ||
| T3b | 124 (5.6%) | 5.24 | 4.27, 6.43 | 1.33 | 0.80, 2.19 | ||
| T4 | 57 (2.6%) | 4.64 | 3.51, 6.13 | 1.30 | 0.75, 2.25 | ||
| N | < 0.001 | 0.083 | |||||
| N0 | 2114 (96%) | – | – | – | – | ||
| N1 | 83 (3.8%) | 3.55 | 2.81, 4.49 | 0.67 | 0.42, 1.06 | ||
| M | < 0.001 | 0.89 | |||||
| M0 | 2090 (95%) | – | – | – | – | ||
| M1 | 107 (4.9%) | 4.53 | 3.68, 5.56 | 1.04 | 0.64, 1.67 | ||
| AFP | < 0.001 | 0.050 | |||||
| Negative/normal; within normal limits | 753 (34%) | – | – | – | – | ||
| Positive/elevated | 1444 (66%) | 1.39 | 1.23, 1.56 | 1.13 | 1.00, 1.28 | ||
| Tumor_size | < 0.001 | < 0.001 | |||||
| ≤ 62 mm | 1629 (74%) | – | – | – | – | ||
| > 62 mm | 568 (26%) | 2.28 | 2.04, 2.56 | 1.74 | 1.50, 2.01 | ||
| Surgery | < 0.001 | < 0.001 | |||||
| Lobectomy | 704 (32%) | – | – | – | – | ||
| Local tumor destruction | 311 (14%) | 1.91 | 1.59, 2.30 | 2.32 | 1.92, 2.81 | ||
| No | 753 (34%) | 4.80 | 4.15, 5.54 | 4.25 | 3.61, 4.99 | ||
| Wedge or segmental resection | 429 (20%) | 1.32 | 1.10, 1.58 | 1.29 | 1.07, 1.56 | ||
| Chemotherapy | < 0.001 | 0.005 | |||||
| No/Unknown | 1352 (62%) | – | – | – | – | ||
| Yes | 845 (38%) | 1.52 | 1.37, 1.70 | 0.84 | 0.74, 0.95 | ||
Significant values are in bold.
an (%); mean (SD).
bHR Hazard ratio, CI Confidence interval.