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Comparison of computational efficiency and capabilities of top HLA typing tools on whole exome data across studies.
| Tool | Number of HLA loci typed | Resolution level | Ranking in terms of memory usage | Ranking in terms of runtime efficiency |
|---|---|---|---|---|
| HLA-HD | 29 | Up to 3 fields | Best (1st) | Best (1st) |
| HISAT-genotype | 24 | Up to 4 fields | Good (2nd) | Good (2nd) |
| HLA*LA | 13 | Up to 3 fields | Fair (3rd) | Fair (3rd) |
| Studies | Thuesen et al., 2022; Claeys et al., 2023 | |||
