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Relationship between chronic wounds and a hypoxic environment. (1) Oxygenase catalyzes the production of oxidants by consuming large amounts of oxygen. (2) Collagen formation and fibroblast proliferation are oxygen dependent. (3) A disrupted vascular supply immediately obstructs oxygen delivery to the wound. (4) Angiogenesis during endothelial cell differentiation also consumes large amounts of oxygen. ROS reactive oxygen species
