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Primary sequence of human parathyroid hormone (sequence from Ensembl.org). The pre- and prosequences are cleaved prior to secretion into the bloodstream. Residues 1 and 2 (diagonally striped) are required for PTH receptor activation. Residues 28-34 (checkered pattern) interact with the extracellular amino domain of the PTH receptor. The C-fragment may be cleaved either prior to or after release from the parathyroid gland.
