Effect of a solvent on the synthesis of 6-phenoxypyrimidine^a.

Entry	Base	Solvent	Time	Yieldb [%]
1	NaOH	DMF	3 h	76
2		DMSO		72
3		MeOH	6 h	60
4		H2O	1 h	81
5	KOH	DMF	2 h	78
6		DMSO		74
7		MeOH	6 h	61
8		H2O	1 h	84
9	KOH	H2O	1 h	78c
10	KOH	H2O	1 h	85d
11	KOH	H2O	18 h	60e
12	KOH	H2O	8 h	80f
13	KOH	H2O	1 h	86 g
14	KOH	H2O	1 h	86 h

^aReaction conditions: 1a (1 mmol), 2a (1.2 mmol), Cu-polymer (10 wt%), base (3 eq.), solvent (3 mL), 100 °C (silicon oil bath).

^bIsolated yield.

^cKOH (2 eq.).

^dKOH (3.5 eq.).

^ert.

^f60 °C.

^g80 °C.

^h2a (1.1 mmol), (80 °C).