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Effects of 6r, 6s, 7c, and imatinib on migration and invasion. (A) Cell migration of GIST-T1 cells was inhibited by treatment (36 h) with 6r, 6s, and 7c (0.005 μM and 0.05 μM). (B) Invasion of GIST-T1 cells was inhibited by treatment (48 h) with 6r, 6s, 7c, and imatinib (0.05 μM). (C,D) Percentage wound healing area and relative invasion cells were calculated using ImageJ. (average ± S.D., n = 3 one-way ANOVA and Tukey’s multiple comparisons test; * p < 0.05).
