Table 1.

Visit schedule

Periods	Screening	Baseline visit	Follow-up visits
Visit	V0	V1	V2	V3	V4
Time point	Day −14 to −1	Day 0	Week 4 (±7 days)	Week 26 (±14 days)	Week 52 (±28 days)
Enrolment
Eligibility screen	x
Informed consent	x
History information	x
Allocation		x
Interventions		x	x	x	x
Assessments
Physical examination		x
Pregnancy test		x
Visual acuity		x	x	x	x
Refraction		x	x	x	x
Slip lamp biomicroscopy		x	x	x	x
Intraocular pressure	x	x	x	x	x
Axial length		x	x	x	x
Visual field		x	x	x	x
Fundus photography		x	x	x	x
Optical coherence tomography		x	x	x	x
Central corneal thickness		x	x	x	x
Adverse events	x	x	x	x	x
Combination drugs	x	x	x	x	x
Drug distribution		x	x	x
Drug recovery and investigation			x	x	x