FIG. 1.

Schematic representation of the capsid-coding region of chimeric FMDVs. Genomic regions of FMDV of serotype C (white boxes) are inserted in the full-length cDNA of type O1K FMDV (3, 65). Origins of the viruses used for construction of chimeric DNA and procedures employed for the preparation of plasmids are detailed in Materials and Methods. Restriction sites and numbering refer to the C-S8c1 genome (21). Positions at which amino acid residues differ among the compared chimeric genomes are indicated at the bottom. The amino acid sequence of protein VP4 is conserved among the FMDVs of serotypes O and C analyzed here. Boldface letters correspond to amino acid residues which differ from the parental C-S8c1.