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. Author manuscript; available in PMC: 2024 Jun 10.
Published in final edited form as: J Med Chem. 2024 May 9;67(10):8323–8345. doi: 10.1021/acs.jmedchem.4c00517

Figure 3.

Figure 3.

In vivo efficacy of 95, 101, and 110 in mice. (A) mice (initially 5 per treatment) infected with L. mexicana were treated with vehicle, 101 and 110 and footpad lesion thickness was measured. p Values were determined by two-tailed paired t-test; (B) Mice infected with RS-LUC-expressing L. mexicana were treated (days 20–29) with vehicle, 95, 101 and 110 and imaged at 6 weeks post-infection. The ratio of Relative Luminescence Units (RLU) for each mouse was calculated by dividing the RLU at day 45 post-infection (pi) by the RLU at day 19, just before treatment was begun. This ratio quantifies the increase in RLU between day 19 and day 45. Statistical significance was determined using ANOVA and Dunnett’s post-test. *** p<0.001, ** p<0.01, * p<0.05.