Table 1.
Demographics and Clinical Characteristics by eGFR Slope.
| Characteristics | All | eGFR slope, mL/min/1.73 m2/year | ||||
|---|---|---|---|---|---|---|
| >50th %ile | 26th-50th %ile | 11th-25th %ile | ≤10th %ile | Missing | ||
| N | 336 376 | 109 741 (32.6) | 54 871 (16.3) | 32 922 (9.8) | 21 948 (6.5) | 116 894 (34.8) |
| eGFR slope | ||||||
| Median | –0.41 | 0.62 | –0.95 | –2.31 | –4.71 | |
| Range | (−109.06, 26.22) | (−0.41, 26.22) | (−1.67,−0.41) | (−3.34,−1.67) | (−48.04,−3.34) | – |
| Age, years | ||||||
| 18–39 | 27 423 (8.2) | 5624 (5.1) | 2481 (4.5) | 1478 (4.5) | 982 (4.5) | 16 858 (14.4) |
| 40–64 | 159 395 (47.4) | 49 926 (45.5) | 24 287 (44.3) | 13 515 (41.1) | 8684 (39.6) | 62 983 (53.9) |
| ≥65 | 149 558 (44.5) | 54 191 (49.4) | 28 103 (51.2) | 17 929 (54.5) | 12 282 (56.0) | 37 053 (31.7) |
| Women | 157 215 (46.7) | 50 974 (46.4) | 25 279 (46.1) | 15 404 (46.8) | 10 579 (48.2) | 54 979 (47.0) |
| Rural residence | 45 193 (13.4) | 14 860 (13.5) | 6995 (12.7) | 4608 (14.0) | 3576 (16.3) | 15 154 (13.0) |
| Duration of diabetes, years | 8 [4, 13] | 8 [4, 13] | 8 [4, 14] | 9 [4, 15] | 10 [5, 17] | 7 [3, 12] |
| HbA1c, % | ||||||
| <7 | 149 597 (44.5) | 58 885 (53.7) | 28 474 (51.9) | 16 344 (49.6) | 10 104 (46.0) | 35 790 (30.6) |
| 7-8 | 61 619 (18.3) | 23 312 (21.2) | 12 837 (23.4) | 7727 (23.5) | 5220 (23.8) | 12 523 (10.7) |
| >8-9 | 25 281 (7.5) | 8914 (8.1) | 4990 (9.1) | 3307 (10.0) | 2412 (11.0) | 5658 (4.8) |
| >9 | 28 816 (8.6) | 8926 (8.1) | 4579 (8.3) | 3203 (9.7) | 2692 (12.3) | 9416 (8.1) |
| Missing | 71 063 (21.1) | 9704 (8.8) | 3991 (7.3) | 2341 (7.1) | 1520 (6.9) | 53 507 (45.8) |
| eGFR, mL/min/1.73 m2 | ||||||
| ≥90 | 101 567 (30.2) | 44 909 (40.9) | 18 842 (34.3) | 5815 (17.7) | 1411 (6.4) | 30 590 (26.2) |
| 60-<90 | 119 820 (35.6) | 45 693 (41.6) | 23 551 (42.9) | 16 877 (51.3) | 9418 (42.9) | 24 281 (20.8) |
| 45-<60 | 30 934 (9.2) | 10 178 (9.3) | 6505 (11.9) | 5506 (16.7) | 5332 (24.3) | 3413 (2.9) |
| 30-<45 | 15 404 (4.6) | 4498 (4.1) | 3427 (6.2) | 2967 (9.0) | 3517 (16.0) | 995 (0.9) |
| 15-<30 | 5480 (1.6) | 1188 (1.1) | 1226 (2.2) | 1178 (3.6) | 1719 (7.8) | 169 (0.1) |
| <15 | 972 (0.3) | 80 (0.1) | 183 (0.3) | 255 (0.8) | 438 (2.0) | 16 (0.0) |
| Missing | 62 199 (18.5) | 3195 (2.9) | 1137 (2.1) | 324 (1.0) | 113 (0.5) | 57 430 (49.1) |
| Albuminuria | ||||||
| None/mild | 178 987 (53.2) | 69 998 (63.8) | 34 896 (63.6) | 19 570 (59.4) | 10 941 (49.8) | 43 582 (37.3) |
| Moderate | 43 654 (13.0) | 16 626 (15.2) | 8965 (16.3) | 5913 (18.0) | 4485 (20.4) | 7665 (6.6) |
| Severe | 15 515 (4.6) | 4686 (4.3) | 2877 (5.2) | 2587 (7.9) | 3354 (15.3) | 2011 (1.7) |
| Missing | 98 220 (29.2) | 18 431 (16.8) | 8133 (14.8) | 4852 (14.7) | 3168 (14.4) | 63 636 (54.4) |
| Comorbidities | 1 [0, 2] | 1 [1, 2] | 1 [1, 2] | 1 [1, 2] | 1 [1, 3] | 1 [0, 1] |
| Cardiovascular disease | 91 097 (27.1) | 33 251 (30.3) | 16 381 (29.9) | 11 493 (34.9) | 9967 (45.4) | 20 005 (17.1) |
| Atrial fibrillation | 25 723 (7.7) | 9529 (8.7) | 4702 (8.6) | 3473 (10.5) | 3377 (15.4) | 4642 (4.0) |
| Chronic heart failure | 31 919 (9.5) | 11 085 (10.1) | 5517 (10.1) | 4470 (13.6) | 5207 (23.7) | 5640 (4.8) |
| Coronary artery disease | 31 917 (9.5) | 11 590 (10.6) | 5860 (10.7) | 4218 (12.8) | 3645 (16.6) | 6604 (5.6) |
| Myocardial infarction | 19 144 (5.7) | 6812 (6.2) | 3374 (6.1) | 2446 (7.4) | 2156 (9.8) | 4356 (3.7) |
| Peripheral artery disease | 9705 (2.9) | 3567 (3.3) | 1758 (3.2) | 1338 (4.1) | 1284 (5.9) | 1758 (1.5) |
| Stroke/TIA | 40 121 (11.9) | 14 915 (13.6) | 7103 (12.9) | 4844 (14.7) | 4088 (18.6) | 9171 (7.8) |
| Diabetic retinopathy | 46 784 (13.9) | 15 960 (14.5) | 8629 (15.7) | 6170 (18.7) | 5130 (23.4) | 10 895 (9.3) |
| Hypertension | 239 947 (71.3) | 85 813 (78.2) | 43 645 (79.5) | 27 185 (82.6) | 19 217 (87.6) | 64 087 (54.8) |
| Prescriptions filled | ||||||
| SGLT2 inhibitor | 38 100 (11.3) | 14 217 (13.0) | 7775 (14.2) | 4926 (15.0) | 3394 (15.5) | 7788 (6.7) |
| ACE inhibitor or ARB | 186 340 (55.4) | 69 033 (62.9) | 36 319 (66.2) | 22 926 (69.6) | 15 964 (72.7) | 42 098 (36.0) |
| Statins | 174 776 (52.0) | 66 916 (61.0) | 34 734 (63.3) | 21 329 (64.8) | 14 500 (66.1) | 37 297 (31.9) |
Note. ACE = angiotensin-converting enzyme; ARB = angiotensin II receptor blockers; eGFR = estimated glomerular filtration rate; HbA1c = glycated hemoglobin; KDIGO = Kidney Disease Improving Global Outcomes; SGLT2 = sodium-glucose cotransporter-2; TIA = transient ischemic attack. n (%) or median [interquartile range].