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. Author manuscript; available in PMC: 2024 Jun 10.
Published in final edited form as: Biomaterials. 2016 Dec 2;118:84–93. doi: 10.1016/j.biomaterials.2016.12.001

Figure 8.

Figure 8.

Aerosolized NPs can deliver siRNA in vivo to surgically implanted orthotopic lung tumors. a) The decrease of luminance intensity in the lung indicates the siLuc-mediated luciferase knockdown in orthotopic A549 tumors after inhalation of siLuc NPs (1 mg/kg siLuc, 400 μL). One of three mice was shown as a representative for each group. b) Efficient luciferase knockdown was confirmed by the decrease of protein normalized luminance in the homogenized lung with aerosol inhalation of siLuc NPs (mean ± s.d., n = 3). n.s. P > 0.05; *P < 0.05; **P < 0.005.