Table 3. Main inborn errors of immunity to be considered according to the malignancy found.

Malignancies	Inborn errors of immunity
Non-Hodgkin and Hodgkin lymphomas, ALL	Combined deficiencies of T and B cells not severe
	Defects of DNA repair
	Predominantly antibody deficiencies
	Diseases of immune dysregulation
MDS, AML	Congenital neutropenia,
	Shwachman-Diamond syndrome,
	GATA2 deficiency,
	Diseases with bone marrow failure
CNS tumors	Defects of DNA repair
Solid tumors	Defects of DNA repair
	Congenital dyskeratosis (telomeropathies)
	PTEN deficiency (APDS-like)
	CVID
Smooth muscle tumors associated with EBV	Combined deficiencies T and B not severe
	Ataxia telangiectasia
	Deficiency of GATA2
	Deficiency of CARMIL2
	Deficiency of ZAP70
Kaposi's sarcoma	Wiskott-Aldrich syndrome
	XMEN syndrome
	Deficiency of IFNg receptor 1
	Deficiency of STIM
	Deficiency of OX40
Skin cancer, not melanoma	Epidermodisplasia verruciformis
	Deficiency of DOCK8
	Cartilage hair hypoplasia
	Xeroderma pigmentosum
	Chronic mucocutaneous candidiasis

ALL: acute lymphoblastic leukemia; MDS: myelodysplastic syndrome; AML: acute myeloid leukemia; CNS: central nervous system; EBV: Epstein-Barr virus; IFNg: interferon gamma. Adapted from Bosh et al. ¹⁶ .