Table 2.
Relationship between the H score of STAT3 and CTLA4 H score and the clinicopathological parameters in the CRC cases (N=113)
| Clinicopathological data | STAT3 H score | CTLA4 H score | |||
|---|---|---|---|---|---|
| Mean± SD | P-value | Mean± SD | P-value | ||
|
Gender
Male Female |
200±66.17 180.89±73 |
U=0.130 | 175.96±79.38 190.27±65.29 |
U=0.435 | |
|
Age
<52 years ≥52 years |
176.44±74.68 206.85±61.5 |
t =0.02* | 154.2±68.6 182.6±70.8 |
U=0.033* | |
|
Clinical presentation
Bleeding per rectum Abdominal pain Constipation Constipation+Bleeding per rectum |
200.2±72.1 166.7±72.8 199.4±63.5 160 |
F=0.172 | 163.98±63 159.5±80.7 175.3±70.6 175.26 |
F=0.298 | |
|
Progression Status
Present Absent |
208.8±60.8 187.2±71.6 |
U=0.218 | 174±86 166.5±67.5 |
U=0.589 | |
|
Site of tumor
RT. colon LT. colon Rectum |
189.5±71.4 188.8±70.5 197.7±69.1 |
F=0.870 | 169.3±74.1 173.8±68.6 154.6±68.8 |
F=0.567 | |
|
Size
<6 ≥6 |
191.4±68.5 190.3±73.3 |
U=0.863 | 174.4±63.7 157.5±80.3 |
U=0.239 | |
|
Gross morphology
Fungating mass Ulcer Infiltrating |
179.7±65.9 196.6±67.1 202.3±78.7 |
KW=0.228 | 162.2±74.8 172.7±68.2 171.1±68.8 |
KW=0.786 | |
|
Gross perforation
Absent Present |
188.5±70.9 223.1±50.6 |
U=0.245 | 166.3±71.8 186.9±56.6 |
U=0.337 | |
|
T Stage
T1 T2 T3 T4 |
206.7±57.7 166.74±68.9 191.33±74 212.2±55.9 |
KW=0.244 | 218.33±86.94 151.74±63.149 183.13±74.36 209.57±67.25 |
KW=0.024* | |
|
N Stage
N0 N1 N2 |
174.7±69.8 213±68 203.5±64.2 |
F=0.026* | 163.3±69.3 179.2±71.9 162.5±75 |
KW=0.546 | |
|
M Stage
M0 M1 |
183.2±71.3 221.3±56.7 |
U=0.016* | 175.61±72.59 212.17±67.32 |
U=0.027* | |
|
AJCC staging
I II III IV |
167±70.8 175.4±69.9 202.8±71 221.3±56.7 |
KW=0.016* | 151.7±65.5 166.5±71.8 163.6±64 190.4±81 |
KW=0.216 | |
|
Histopathological type
Conventional adenocarcinoma Mucinous Mixed |
189.44±70.8 202.9±70.3 190±69.7 |
KW=0.430 | 169.2±72.5 174.6±73.7 158±64.3 |
KW=0.802 | |
|
Grading
High Low |
231.72±176.9 179.9±69.9 |
U<0.001** | 190.3±81.1 160±65.6 |
U=0.03* | |
|
Association with adenoma in bowel
Present Absent |
191.9±75.3 190.8±69.6 |
U=0.960 | 157.5±74.4 169.5±70.44 |
U=0.530 | |
|
Lymphovascular invasion
Positive Negative |
191.8±72.5 190.8±70 |
U=0.817 | 172.4±75.8 166.98±70.3 |
U=0.815 | |
|
Perineural invasion
Positive Negative |
205.4±66.8 189.3±70.6 |
U=0.505 | 183.8±71 165.9±70.9 |
0.403 | |
|
Necrosis
Absent Present |
190.4±71.2 193±66.8 |
U=0.954 | 169.6±66.7 160.9±86 |
U=0.622 | |
|
Margins
Free Involved |
189.1±70 258.3±23.6 |
U=0.019* | 168.6±71 138.3±67.9 |
U=0.489 | |
|
Mitotic count
<7 ≥7 |
157±65.8 183±77.3 |
U=0.001** | 150.8±82.9 157.8±61.6 |
U=0.028* | |
|
Tumor budding score
High Intermediate Low |
212.4±64.9 212.3±68.6 172.3±68.8 |
F=0.008* | 188.4±76.4 158.6±63.5 160.5±69.3 |
U=0.038* | |
|
Tumor border configuration
Infiltrating Pushing |
217.98±62.98 167.95±67.97 |
U<0.001** | 201.63±73.36 167.21±68.97 |
U=0.007* | |
|
CEA
Unknown Normal High |
184.2±66.9 188.3±73.8 217.8±61.9 |
KW=0.366 | 167.7±66.9 166.4±69.5 172.8±87.9 |
KW=0.873 | |
|
CA19.9
Unknown Normal High |
184.2±66.8 194.4±73.8 196.8±66.6 |
KW=0.748 | 167.7±66.9 1655±67.9 177.5±95 |
KW=0.078 | |
|
Initial presentation of Intestinal obstruction
Yes No |
208.5±64 184.6±71.4 |
U=0.101 | 188.3±78.5 160.4±66.7 |
U=0.037* | |
|
KRAS
Mutant Unknown |
245±31.2 189.5±70.3 |
U=0.234 | 200±17.3 166.9±71.5 |
t=0.049* | |
t = student t test U= Mann-Whitney test KW=Kruskal Wallis test F= One Way ANOVA
*P-value of < 0.05: statistically significant **P-value of < 0.001: statistically highly significant.