Table 3.

The multivariate COX regression for detection of the independent factors affecting patient overall survival

Predictors (Independent variables)	Hazard ratio	95% CI (lower-upper)	P-value
Size ≥ 6 cm	2.070	0.754 – 5.683	0.158
T Stage T2 T3 T4	1.723 4.930 2.493	0.558 – 5.321 1.615 – 15.048 1.476 – 4.211	0.344 0.005* 0.001*
Lymphovascular invasion Positive	2.640	0.859 – 8.119	0.09
Margins Involved	3.229	0.726 – 14.370	0.124
Tumor border configuration Infiltrating	1.285	0.310 – 5.323	0.730
High CEA	1.541	0.423 – 5.616	0.512
High CA19.9	0.411	0.066 – 2.558	0.341
Initial presentation of IO	3.331	1.223 – 9.07	0.019*
STAT3 H score (≥190)	3.547	1.023 – 12.302	0.046*
CTLA4 H score (≥190)	1.460	0.546 – 3.904	0.451