Table 4.
The multivariate COX regression for detection of the independent factors affecting patient PFS
| Predictors (Independent variables) | Hazard ratio |
95% CI (lower-upper) | P-value |
|---|---|---|---|
| Gross perforation | 0.565 | 0.005 – 5.785 | 0.630 |
|
Size
≥6 cm |
1.964 | 0.342 – 11.271 | 0.449 |
|
T Stage
T4 |
11.483 | 1.012 – 130.319 | 0.04* |
|
M Stage
M1 |
1.132 | 0.161- 7.934 | 0.901 |
| Positive Lymph vascular invasion | 1.109 | 0.262 – 4.695 | 0.888 |
| Positive perineural invasion | 1.779 | 0.412 – 7.689 | 0.440 |
| Involved Margins | 4.981 | 0.287-86.445 | 0.270 |
|
Mitotic count
≥7 |
22.109 | 2.104-232.286 | 0.01* |
| Infiltrating Tumorborder configuration | 0.027 | 0- 5.88 | 0.189 |
| High CEA | 1.162 | 0.157 – 8.593 | 0.883 |
| Initial presentation of IO | 0.350 | 0.07 – 1.754 | 0.202 |
|
STAT3 H score
≥190 |
21.762 | 1.219 – 388.458 | 0.036* |
|
CTLA4 H score
≥190 |
2.669 | 0.424 – 16.785 | 0.296 |
PFS: progression-free survival
CI: Confidence interval
T stage: tumor depth stage
M stage: presence of the tumor metastasis
IO: intestinal obstruction
*P-value<0.05: statistically significant
**P-value<0.001: statistically highly significant.