Table 2.
Univariable logistic regression and doubly robust regression analyses of outcomes according to treatment (EVT+/-IVT vs. IVT alone)
| EVT+/-IVT (n=400) | IVT (n=324) | P | OR (95% CI)† | aOR (95% CI)‡ | Missing data | |
|---|---|---|---|---|---|---|
| mRS at 3 months | 2 (1–4) | 2 (1–3) | 0.27 | 0.86 (0.66–1.12)§ | 1.07 (0.79–1.43)§ | 41/28 |
| mRS 0–1 at 3 months | 114 (31.8) | 84 (28.4) | 0.39 | 1.17 (0.84–1.64) | 1.39 (0.96–2.02)ǁ | 41/28 |
| mRS 0–2 at 3 months | 181 (50.4) | 165 (55.7) | 0.18 | 0.81 (0.59–1.10) | 1.07 (0.73–1.58) | 41/28 |
| ENI | 236 (64.7) | 164 (53.2) | <0.01* | 1.61 (1.18–2.19)* | 1.49 (1.05–2.12)* | 35/16 |
| Mortality | 58 (16.2) | 30 (10.1) | 0.03* | 1.71 (1.07–2.74)* | 1.77 (1.07–2.95)*ǁ | 41/28 |
| sICH | 24 (6.1) | 8 (2.5) | 0.03* | 2.55 (1.13–7.75)* | 2.87 (1.23–6.72)*ǁ | 4/0 |
Values are presented as median (interquartile range) or n (%) unless otherwise indicated.
EVT, endovascular thrombectomy; IVT, intravenous thrombolysis; OR, odds ratio; CI, confidence interval; aOR, adjusted OR; mRS, modified Rankin Scale; ENI, early neurological improvement; sICH, symptomatic intracerebral hemorrhage.
P<0.05;
Univariable generalized estimating equation analysis using multinomial distribution and cumulative logit link function (mRS shift) or binomial distribution and logit link function (other outcomes);
Doubly robust regression model (inverse probability weighted regression adjustment model) including treatment group (EVT+/-IVT vs. IVT alone), age, sex, hypertension, diabetes, atrial fibrillation, NIHSS score at baseline, posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) at baseline, level of occlusion, and year of treatment;
Common OR;
The model did not converge with the level of occlusion, so it was excluded.