Table 1.
Baseline characteristics of patients with medium vessel occlusions
| Characteristics | IV Tenecteplase (n=236) | IV Alteplase (n=219) | P |
|---|---|---|---|
| Baseline characteristics | |||
| Age (yr) | 77 (65–84) | 76 (66–84) | 0.83 |
| Female sex | 107 (45.3) | 103 (47.0) | 0.78 |
| Baseline NIHSS | 8 (5–14) | 8.5 (6–14) | 0.14 |
| Workflow times (min) | |||
| Onset to hospital arrival (n=450) | 87 (55–142) | 87 (55–145) | 0.77 |
| Onset to needle (n=452) | 136 (98–190) | 130 (95–191) | 0.97 |
| Hospital arrival to needle (n=440) | 39 (30–53) | 36 (30–50) | 0.38 |
| Hospital arrival to arterial access (in patients undergoing EVT; n=85) | 85 (66–117) | 91 (63–113) | 0.85 |
| Imaging to reperfusion assessment (in patients undergoing EVT; n=84) | 86 (65–107) | 84 (57–115) | 0.82 |
| Arterial access to successful reperfusion (in patients undergoing EVT; n=79) | 32 (22–55) | 35.5 (18.5–49) | 0.66 |
| Type of enrolling center | 0.42 | ||
| Primary stroke center | 15 (6.4) | 10 (4.6) | |
| Comprehensive stroke center | 221 (93.6) | 209 (95.4) | |
| EVT utilization | 47 (19.9) | 40 (18.3) | 0.72 |
| Imaging characteristics | |||
| Occlusion location | 0.70 | ||
| Proximal non-dominant M2 | 68 (28.8) | 57 (26.0) | |
| Distal M2 | 42 (17.8) | 32 (14.6) | |
| M3/M4 | 79 (33.5) | 81 (37.0) | |
| A2 | 3 (1.3) | 3 (1.4) | |
| A3/A4 | 15 (6.4) | 13 (5.9) | |
| P2 | 24 (10.2) | 26 (11.9) | |
| P3/P4 | 5 (2.1) | 7 (3.2) | |
| Collateral grade (MCA occlusions, n=359) | 0.26 | ||
| Poor | 8/189 (4.2) | 5/170 (2.9) | |
| Intermediate | 44/189 (23.3) | 52/170 (30.6) | |
| Good | 137/189 (72.5) | 113/170 (66.5) | |
| ASPECTS (MCA occlusions, n=359) | 10 (9–10) | 10 (9–10) | 0.57 |
Data are median (interquartile range) or n (%).
IV, intravenous; NIHSS, National Institutes of Health Stroke Scale; EVT, endovascular thrombectomy; ASPECTS, Alberta Stroke Program Early CT Score; MCA, middle cerebral artery.