Table 1.
Patient Characteristics
| Variable | Overall N = 622 |
Reinstituted N = 287 |
Liberated N = 335 |
p-value | |
|---|---|---|---|---|---|
| Patient Baseline Characteristics | |||||
| Age (years) | 9.0 (2.0, 14.9) | 10.8 (2.5, 15.2) | 6.2 (1.8, 14.4) | 0.04 | |
| Gender (female) | 286 (46%) | 141 (49%) | 145 (43%) | 0.2 | |
| Primary Comorbidities: None | 146 (23%) | 62 (22%) | 84 (25%) | 0.4 | |
| Primary Comorbidities: Renal/Urologic | 64 (10%) | 41 (14%) | 23 (6.9%) | 0.004 | |
| Primary Comorbidities: Immunologic | 78 (13%) | 47 (16%) | 31 (9.3%) | 0.011 | |
| Admission Characteristics | |||||
| Admission weight (kg) | 28.9 (12.7, 58.2) | 35.3 (13.8, 60.0) | 23.8 (11.5, 52.6) | 0.006 | |
| Admission Category | 0.3 | ||||
| Shock/Infection/Major Trauma | 234 (38%) | 101 (35%) | 133 (40%) | ||
| Respiratory Failure | 98 (16%) | 49 (17%) | 49 (15%) | ||
| Other | 152 (24%) | 79 (27%) | 73 (22%) | ||
| Illness Severity Parameters | |||||
| Sepsis at ICU Admission1 | 262 (42%) | 129 (45%) | 133 (40%) | 0.2 | |
| PELOD-22 Score at CRRT Initiation | 6 (4, 8) | 6 (3.5, 8) | 6 (4, 8) | 0.11 | |
| PELOD-2 Score at CRRT Liberation Attempt | 5 (3, 7) | 5 (2.5, 7) | 5 (3, 7) | 0.15 | |
| VIS3 at CRRT Initiation | 3 (0,15) | 0 (0, 11.2) | 5 (0, 20) | <0.001 | |
| VIS at CRRT Liberation Attempt | 0 (0, 3) | 0 (0, 2) | 0 (0, 3.3) | 0.2 | |
| PRISM-III4 Score at ICU Admission | 14 (9, 18) | 13 (9, 18) | 14 (10, 18) | 0.3 | |
| Time from ICU admission to CRRT initiation (days) | 2 (1, 5) | 2 (1, 5) | 2 (1, 4.5) | 0.6 | |
| Fluid Balance Parameters | |||||
| Urine output 24 h prior to CRRT initiation (ml/kg/h) | 0.5 (0.1, 1.3) | 0.4 (0.4, 1.11) | 0.5 (0.2, 1.5) | 0.08 | |
| Urine output 6h prior to CRRT liberation attempt (ml/kg/h) with loop diuretic | 0.5 (0.1, 1.5) N = 214 |
0.4 (0.1, 1.2) N = 107 |
0.70 (0.1, 2.1) N = 107 |
0.08 | |
| Time to first day of negative Fluid Balance (FB5) | 0.022 | ||||
| Day 0 | 243 (39%) | 113 (40%) | 130 (39%) | ||
| Day 1 | 211 (34%) | 106 (37%) | 105 (31%) | ||
| Fluid Balance Never Negative | 66 (11%) | 16 (5.6%) | 50 (15%) | <0.001 | |
| Cumulative Fluid Balance Percent (%cFB6) from ICU admission to CRRT initiation | 7.2 (2.1, 16.8) | 7.4 (1.9, 17.3) | 7.0 (2.2, 16.8) | 0.8 | |
| %cFB from ICU admission to CRRT day 3 | −21.5 (−71.1, 25.3) N =456 |
−20.3 (−73.4, 21.0) N = 223 |
−23.4 (−70.4, 29.7) N =233 |
0.8 | |
| % daily fluid balance day 4 (ml/kg) | −3.4 (−23.7, 8.8) N=373 |
−1.2 (−18.1, 8.4) N=183 |
−8.1 (−29.8, 8.7) N=190 |
0.02 | |
| % daily fluid balance day 5 (ml/kg) | −3.6 (−19.3, 12.3) N=304 |
0.1 (−16.2, 15.8) N=162 |
−6.4 (−21.9, 6.6) N=142 |
0.03 | |
Categorical variables are presented as n (%) and Continuous variables as median (IQR); P-values calculated using chi-square test or Wilcoxon rank sum test.
1
ICU: Intensive Care Unit
2
PELOD-2: Pediatric logistic organ dysfunction score
3
VIS: Vasoactive-inotrope score
4
PRISM-III: Pediatric risk of mortality III score
5
FB: Fluid Balance
6
%cFB: Cumulative fluid balance percent