Table 3.
Multivariable regression model predicting successful CRRT liberation (n = 601).
| Significant Predictor Variables | Reference | Contrast | OR (95%CI) |
|---|---|---|---|
| Primary Comorbidities: Renal/Urologic | No | Yes | 0.38 (0.20-0.75) |
| Vasopressor-Inotrope Score at CRRT1 Initiation | 0.0 | 20.0 | 1.35 (1.12-1.63) |
| Vasopressor-Inotrope Score at Liberation Attempt | 0.0 | 3.6 | 0.99 (0.98-0.999) |
| PELOD-22 Score at CRRT Initiation | 4.0 | 9.0 | 1.71 (1.24 - 2.35) |
| Urine output (24h prior to CRRT Initiation) (ml/kg/h) | 0.1 | 1.2 | 1.15 (1.001-1.32) |
| CRRT duration (days) | 3.0 | 14.0 | 0.19 (0.12-0.28) |
Odds ratio (OR) and 95% confidence intervals (CI) obtained by logistic regression. The model accounts for the nesting of patients within hospitals via the Huber-While cluster sandwich estimator of variance. ORs for continuous predictors scaled to reflect the interquartile range odds ratio (i.e., reference = 25th percentile, contrast = 75th percentile). Other variables adjusted for include the following: weight, presence of no comorbidities, cardiac comorbidity, oncologic comorbidity, immunologic comorbidity, sepsis at ICU3 admission, PELOD-2 score at crrt liberation attempt, % fluid balance (ICU admit to CRRT initiation), calculated CRRT dose, time from ICU admission to CRRT initiation. 21 (3.4%) out of 622 patients were not included in the analysis due to missing covariate data.
CRRT: Continuous Renal Replacement Therapy
PELOD-2: Pediatric logistic organ dysfunction score
ICU: Intensive Care Unit