Fig. 4.

CD8⁺ T cell Responses to SARS-CoV-2 Spike Peptides in Negative, Asymptomatic and Symptomatic Adults. The percentage of activated spike-specific CD8⁺ T cells in response to Wuhan (Ai) and Omicron (Aii) peptides. The percentage of cytokine-positive CD8⁺ T cells in response to Wuhan (Bi) and Omicron (Bii) spike peptides. Cytokine combinations expressed by Wuhan (Ci) and Omicron (Cii) spike-specific CD8⁺ T cells. Total N=102 (9 Negative Unvaccinated, 9 Negative Vaccinated, 23 Asymptomatic Unvaccinated, 23 Asymptomatic Vaccinated, 19 Symptomatic Unvaccinated, 19 Symptomatic Vaccinated). Light blue bars = negative participants, dark blue bars = asymptomatic participants, green bars = symptomatic participants