Table 2.

Definition of disseminated intravascular coagulation according to the criteria of the International Society on Thrombosis and Haemostasis [46] and the modified Japanese Ministry of Health and Welfare criteria [47]

Criteria	ISTH	JMHWa	Score
Clinical symptoms	NA	Organ failure	1
Platelet count (G/L)	> 100 50–100 < 50	NA	0 1 2
d-dimers or FDP	No increase Moderate increase Severe increase	FDPs ≥ 20	0 1 2
PT increase (s)b or PT ratio	< 3 s 3–6 s > 6 s	1.25–1.67 (PT ratio) > 1.67 (PT ratio)	0 1 2
Fibrinogen (g/L)	≥ 1 < 1	NA	0 1
Diagnosis of DIC	≥ 5 points	≥ 4 points

DIC disseminated intravascular coagulation, FDP fibrin degradation products, ISTH International Society on Thrombosis and Haemostasis, JMHW Japanese Ministry of Health and Welfare, NA not applicable, PT prothrombin time, s second

^aJMWH criteria are modified for patients with thrombocytopenia of central origin, including bone marrow invasion by hematological malignancies [47]. These modified criteria do not include points for platelet count or bleeding

^bThe value of prothrombin time increase is given in second(s) above the normal upper limit