Table 3.
Maternal report of use of medications containing acetaminophen during pregnancy in the IKIDS cohort.
| Participants with an infant enrolled in study & exposure data available | Participants who completed the CDI when their child was 26.5-28.5 months | |||||||
|---|---|---|---|---|---|---|---|---|
| (n = 532) | (n = 298) | |||||||
| 1st Trimester | 2nd Trimester | 3rd Trimester | Entire Pregnancy | 1st Trimester | 2nd Trimester | 3rd Trimester | Entire Pregnancy | |
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |
| None | 220 (41.4) | 249 (46.8) | 338 (63.5) | 155 (29.1) | 129 (43.3) | 148 (49.7) | 197 (66.1) | 90 (30.2) |
| Any | 312 (58.6) | 283 (53.2) | 194 (36.5) | 377 (70.9) | 169 (56.7) | 150 (50.3) | 101 (33.9) | 208 (69.8) |
| Mean (SD) number of times taken | 17.9 (39.7) | 22.0 (44.1) | 15.1 (25.6) | 39.1 (75.1) | 14.5 (26.8) | 20.1 (44.9) | 13.2 (21.6) | 32.7 (66.0) |
| Median (IQR) number of times taken | 5.0 (14.0) | 7.5 (15.0) | 5.0 (12.0) | 14.0 (31.8) | 6.0 (13.5) | 7.0 (13.8) | 4.8 (11.3) | 12.4 (29.6) |
| Range number of times taken | 0.5–314.0 | 0.5–350.0 | 0.5–153.0 | 1.0–641.0 | 1.0–248.5 | 0.5–339.0 | 0.5–119.5 | 1.0–550.5 |
| Formulation | ||||||||
| Paracetamol alone | 258 (82.7) | 229 (80.9) | 158 (81.4) | 287 (76.1) | 140 (82.8) | 121 (80.7) | 83 (82.2) | 158 (76.0) |
| Paracetamol in combination | 25 (8.0) | 19 (6.7) | 17 (8.8) | 26 (6.9) | 16 (9.5) | 15 (10.0) | 10 (9.9) | 19 (9.1) |
| with other active ingredients | ||||||||
| Multiple formulations | 29 (9.3) | 35 (12.4) | 19 (9.8) | 64 (17.0) | 13 (7.7) | 14 (9.3) | 8 (7.9) | 31 (14.9) |
| Indication | ||||||||
| Pain | 214 (68.6) | 202 (71.4) | 134 (69.1) | 235 (62.3) | 110 (65.1) | 102 (68.0) | 68 (67.3) | 118 (56.7) |
| Other | 39 (12.5) | 31 (11.0) | 26 (13.4) | 54 (14.3) | 23 (13.6) | 20 (13.3) | 14 (13.9) | 36 (17.3) |
| Multiple reasons given | 27 (8.7) | 28 (9.9) | 19 (9.8) | 61 (16.2) | 16 (9.5) | 12 (8.0) | 10 (9.9) | 36 (17.3) |
| Missing | 32 (10.3) | 22 (7.8) | 15 (7.7) | 27 (7.2) | 20 (11.8) | 16 (10.7) | 9 (8.9) | 18 (8.7) |
| Participants who completed the SLAS when their child was 36–38 months | ||||
|---|---|---|---|---|
| (n = 254) | ||||
| 1st Trimester | 2nd Trimester | 3rd Trimester | Entire Pregnancy | |
| N (%) | N (%) | N (%) | N (%) | |
| None | 111 (43.7) | 123 (48.4) | 169 (66.5) | 80 (31.5) |
| Any | 143 (56.3) | 131 (51.6) | 85 (33.5) | 174 (68.5) |
| Mean (SD) number of times taken | 13.2 (27.1) | 21.9 (47.6) | 14.7 (24.2) | 34.5 (70.2) |
| Median (IQR) number of times taken | 4.5 (11.0) | 8.0 (14.5) | 5.0 (12.0) | 13.0 (29.0) |
| Range number of times taken | 1.0–248.5 | 0.5–339.0 | 0.5–119.5 | 1.0–550.5 |
| Formulation | ||||
| Acetaminophen alone | 118 (82.5) | 105 (80.2) | 69 (81.2) | 133 (76.4) |
| Acetaminophen in combination | 15 (10.5) | 13 (9.9) | 9 (10.6) | 16 (9.2) |
| with other active ingredients | ||||
| Multiple formulations | 10 (7.0) | 13 (9.9) | 7 (8.2) | 25 (14.4) |
| Indication | ||||
| Pain | 92 (64.3) | 86 (65.6) | 56 (65.9) | 96 (55.2) |
| Other | 22 (15.4) | 18 (13.7) | 12 (14.1) | 31 (17.8) |
| Multiple reasons given | 10 (7.0) | 12 (9.2) | 7 (8.2) | 29 (16.7) |
| Missing | 19 (13.3) | 15 (11.5) | 10 (11.8) | 18 (10.3) |
SD standard deviation, IQR interquartile range.