Table 5.
Odds ratios (odds, 95% CI) of children with prenatal acetaminophen exposure having a percentile score ≤25th percentile adjusted for child sex and age.
| Outcome | Stratified by Sex | |||
|---|---|---|---|---|
| Unadjusted | Exposure | Main Effect | Females | Males |
| Vocabulary | 1st Trimester | 1.003 (0.99, 1.01) | †1.02 (0.99, 1.04) | 0.99 (0.98, 1.01) |
| 2nd Trimester | 1.01 (0.99, 1.01) | 1.01 (0.99, 1.02) | 1.004 (0.99, 1.01) | |
| 3rd Trimester | †1.02 (0.99, 1.03) | 1.02 (0.99, 1.04) | 1.01 (0.99, 1.04) | |
| Entire Pregnancy | 1.003 (0.99, 1.01) | †1.01 (0.99, 1.01) | 1.001 (0.99, 1.01) | |
| Mean Length of Utterance | 1st Trimester | 0.996 (0.98, 1.01) | 0.99 (0.97, 1.02) | 0.99 (0.96, 1.02) |
| 2nd Trimester | 1.004 (0.99, 1.01) | 1.01 (0.99, 1.02) | 0.99 (0.98, 1.02) | |
| 3rd Trimester | †1.02 (0.99, 1.04) | 1.01 (0.99, 1.03) | †1.03 (0.99, 1.07) | |
| Entire Pregnancy | 1.002 (0.99, 1.01) | 1.003 (0.99, 1.01) | 1.001 (0.99, 1.01) | |
| Complexity | 1st Trimester | 1.003 (0.99, 1.02) | 1.01 (0.99, 1.03) | 0.93 (0.77, 1.12) |
| 2nd Trimester | 1.001 (0.99, 1.01) | 1.01 (0.99, 1.02) | 0.99 (0.92, 1.06) | |
| 3rd Trimester | 1.02 (0.99, 1.04) | 1.003 (0.97, 1.03) | *1.04 (1.01, 1.09) | |
| Entire Pregnancy | 1.002 (0.99, 1.01) | 1.004 (0.99, 1.01) | 1.00 (0.99, 1.01) | |
| Adjusteda | ||||
| Vocabulary | 1st Trimester | 1.002 (0.99, 1.01) | 1.02 (0.99, 1.04) | 0.99 (0.98, 1.01) |
| 2nd Trimester | 1.01 (0.99, 1.01) | 1.01 (0.99, 1.02) | 1.003 (0.99, 1.01) | |
| 3rd Trimester | †1.02 (0.99, 1.03) | 1.02 (0.99, 1.04) | 1.01 (0.99, 1.04) | |
| Entire Pregnancy | 1.003 (0.99, 1.01) | 1.01 (0.99, 1.01) | 1.001 (0.99, 1.01) | |
| Mean Length of Utterance | 1st Trimester | 0.99 (0.98, 1.01) | 0.99 (0.97, 1.02) | 0.99 (0.96, 1.03) |
| 2nd Trimester | 1.003 (0.99, 1.01) | 1.004 (0.99, 1.01) | 0.99 (0.98, 1.02) | |
| 3rd Trimester | †1.02 (0.997, 1.04) | 1.01 (0.98, 1.03) | *1.05 (1.01, 1.09) | |
| Entire Pregnancy | 1.002 (0.99, 1.01) | 1.002 (0.99, 1.01) | 1.003 (0.99, 1.01) | |
| Complexity | 1st Trimester | 1.01 (0.99, 1.02) | 1.01 (0.99, 1.03) | 0.95 (0.78, 1.15) |
| 2nd Trimester | 1.003 (0.99, 1.02) | 1.003 (0.99, 1.02) | 0.99 (0.93, 1.05) | |
| 3rd Trimester | 1.02 (0.99, 1.04) | 1.003 (0.97, 1.04) | *1.07 (1.01, 1.13) | |
| Entire Pregnancy | 1.003 (0.99, 1.01) | 1.003 (0.99, 1.01) | 1.004 (0.99, 1.02) | |
aAll models were adjusted for maternal parity, maternal education, mean perceived stress during pregnancy, and mean depression during pregnancy.
†p < 0.10; *p < 0.05; **p < 0.01.