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. 2024 Jun 10;14:13352. doi: 10.1038/s41598-024-64189-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fluoroscopic and cone beam CT (CBCT) imaging following injection of 4 mL of POL22 with iodine or iodine alone at 10 mL/h into ex vivo bovine liver. Three needles were used: SEHN, MSHN, and MPIN deployed at 1 cm (MPIN-1cm) and deployed at 2 cm (MPIN-2cm). (a) Fluoroscopic images following injection of POL22 with iodine with SEHN, MSHN and MPIN-2cm showing the gel deposition (higher density areas) relative to the needle locations. (b) POL22 with iodine injections. 3D surface renderings (left) and corresponding cross-sectional images (right) based on CBCT imaging. (c) Injections of iodine alone. 3D surface renderings (left) and corresponding cross-sectional images (right) based on CBCT imaging.