Table 1.
Heyndrickxia coagulans Strain-Specific Secondary Metabolite Biosynthetic Gene Clusters Identified by AntiSMASH.
| Strain | Antismash-type(size) | Most similar known cluster(Similarity) |
|---|---|---|
| H. coagulans ASRS217 | 1.T3PKS(215185–256357) 2.RiPP-like(2659400–2669738) 3.Betalactone(2892294–2920089) 4.RiPP-like(3393893–34064120) |
2.Amylocyclicin(50%) 3.Fengycin(33%) |
| H. coagulans BC01 | T3PKS(226977–268149) Thiopeptide(1073808–1098825) RiPP-like(2672264–2682602) Betalactone(2914924–2943305) Terpene(2956623–2978488) RiPP-like(3426725–3436952) |
3. Amylocyclicin(50%) 4. Fengycin (40%) 5.Legonindolizidine(8%) |
| H. coagulans DSM 2314 | 1.RiPP-like(323230–333568) 2.Betalactone(529699–557495) 3.RiPP-like(1018620–1028847) 4.LAP(1238486–1261580) 5.T3PKS(1413480) |
1.Amylocyclicin(50%) 2.Fengycin (33%) 4.listeriolysin S (37%) |
| H. coagulans FDAARGOS_1160 | T3PKS(1573717–1614889) Epipeptide(2191893–2213615) |
– |
| H. coagulans HOM5301 | T3PKS(217822–258994) Thiopeptide,LAP(1107940–1132955) RiPP-like(2713700–2724038) Betalactone(2929010–2956802) |
3.Amylocyclicin(50%) 4.Fengycin (40%) |
| H. coagulans IDCC1201 | RiPP-like(1947678–1958016) Betalactone(2124507–2153007) RiPP-like(2645063–2655290) T3PKS(3073385–3114569) |
1.Amylocyclicin(50%) 2.Fengycin (40%) |
| H. coagulans JBI-YZ6.3 | T3PKS(225228–266412) RiPP-like(2692626–2702964) Betalactone(2879246–2907064) Terpene(2909196–2931061) Epipeptide(3182649–3204371) RiPP-like(3371682–3381909) |
1.Amylocyclicin(50%) 2.Fengycin (33%) 3.Legonindolizidine(8%) |
| H. coagulans LA204 | LAP(89293–112397) T3PKS(266003–307187) RiPP-like(2817380–2827718) Betalactone(3021109–3048905) RiPP-like(3511998–3522225) |
1. listeriolysin S (37%) 3.Amylocyclicin(50%) 4.Fengycin (33%) |
| H. coagulans S-lac | RiPP-like(244719–255057) Betalactone(421549–450049) RiPP-like(943737–953964) T3PKS(1368873–1410057) |
1.Fengycin (40%) |
| H. coagulans terpene | Thiopeptide,LAP(362914–387931) RiPP-like(1964777–1975115) Betalactone(2194844–2223225) Terpene(2236543–2258408) RiPP-like(2706642–2716869) T3PKS(3115159–3156331) |
2.Amylocyclicin(50%) 3.Fengycin (33%) 4.Legonindolizidine(8%) |
| H. coagulans ATCC 7050 | Epipeptide(1853126–1874848) T3PKS(2513409–2554581) |
2.locillomycin/locillomycin B/locillomycin C |
| H. coagulans VHProbi C08 | 1.T3PKS(274569–315753) 2.RiPP-like(2820698–2831036) 3.Betalactone(2997528–3026028) 4.RiPP-like(3519649–3529876) |
3.Fengycin (40%) |