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. 2024 Jun 8;6(2):lqae066. doi: 10.1093/nargab/lqae066

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© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Sizes of clades used to confirm current canonical isoform assignments (A, C), or to propose changes in the canonical isoform (B, D). Each line (color) indicates the UniProt release also plotted in Figure 6. Numbers in parentheses in the legend number show the numbers of proteomes used to construct the gap-distance trees from which the clades were identified; this is the largest possible size of a clade (also shown with the black dashed vertical lines). The numbers after the maximum clade size indicate the number of orthogroups that had a confirmed (A, C) or proposed (B, D) clade. Asterisks (*, **) indicate changes in the dog proteome mapping and the horse proteome. An additional 22 proteomes were added for release 2024_01. (A, B) all confirmed or proposed clades. (C, D) confirmed or proposed clades that include a human protein that was selected by MANE (13).