Table 2.
Characteristics of subjects with sinonasal cancer (SNC) by gender, Lombardy Region SNC Registry, Italy, 2008–20
| Men | Women | P valuea | |
|---|---|---|---|
| n (%) | n (%) | ||
| All subjects | 553 (100) | 274 (100) | |
| Age (median, min-max) | 69.0 (25.7–93.1) | 68.3 (21.1–99.7) | 0.18 |
| Cancer site (ICD-10 code) | |||
| Nasal cavity (C30.0) | 215 (39) | 99 (36) | 0.005 |
| Maxillary sinus (C31.0) | 95 (17) | 72 (26) | |
| Ethmoidal sinus (C31.1) | 73 (13) | 21 (8) | |
| Frontal sinus (C31.2) | 2 (0) | 3 (1) | |
| Sphenoidal sinus (C31.3) | 13 (2) | 11 (4) | |
| Multiple sites (C31.8) | 155 (28) | 68 (25) | |
| Cancer morphology (WHO 2017) | |||
| Squamous cell carcinoma and variants | 255 (46) | 145 (53) | 0.03 |
| Adenocarcinoma | 214 (39) | 78 (28) | |
| Neuroendocrine carcinoma | 19 (3) | 7 (3) | |
| Other | 55 (10) | 32 (12) | |
| Malignant tumour | 2 (0) | 2 (1) | |
| Unknown | 8 (1) | 10 (4) | |
| Interview | |||
| Patient | 352 (64) | 159 (58) | 0.05 |
| Relative | 133 (24) | 64 (23) | |
| Not performed | 68 (12) | 51 (19) | |
| Occupational exposureb | |||
| Never exposed | 268 (55) | 187 (84) | |
| Ever exposed (any agent) | 217 (45) | 36 (16) | <0.001 |
| Wood dust | 150 (31) | 13 (6) | <0.001 |
| Leather dust | 65 (13) | 20 (9) | 0.09 |
| Nickel compounds | 9 (2) | 3 (1) | 0.63 |
| Chromium compounds | 18 (4) | 3 (1) | 0.09 |
| Formaldehyde | 3 (1) | 1 (0) | 0.78 |
| Cigarette smoking | |||
| Never | 154 (28) | 122 (45) | <0.001 |
| Former | 207 (37) | 55 (20) | |
| Current | 162 (29) | 74 (27) | |
| Unknown | 30 (5) | 23 (8) | |
ICD-10, International Classification of Diseases, 10th Edition.
aFrom chi-squared test, except for age (Wilcoxon rank-sum test).
bPercentages calculated taking as denominators interviewed subjects (485 men, 223 women).