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. 2024 Jun 11;25(4):bbae282. doi: 10.1093/bib/bbae282

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© The Author(s) 2024. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of particle picking by crYOLO, Topaz and CryoSegNet on three cryo-EM micrographs of two protein types (EMPIAR ID 10345 and EMPIAR ID 11056). (A) Topaz picks ice patches and more particles in the contaminated regions than CryoSegNet while crYOLO picks few particles (EMPIAR ID 10345). (B) Topaz picks more false positives (particularly the ones on the black ice patch) compared to CryoSegNet (EMPIAR ID 10345). (C) CryoSegNet picks a zero to small number of particles in undesired (carbon or ice) regions (black holes) of the micrograph (EMPIAR ID 11056), while Topaz picks some false particles in the regions.