Table 3.
Results of the cytokine/chemokines levels after BCoV infection between the intranasal and oral groups.
| Factors | Two-way RMANOVA | Post-hoc analysis | ||
|---|---|---|---|---|
| Infection time | Inoculation route | Interaction of variables | ||
| IFN-γ | 0.222 | 0.611 | 0.392 | |
| IL-6 | 0.620 | 0.581 | 0.861 | |
| IL-10 | 0.039* | 0.235 | 0.584 | 0.020* |
| IL-17A | 0.691 | 0.943 | 0.341 | |
| IL-36RA | 0.121 | 0.188 | 0.542 | |
| IL-8 | 0.000*** | 0.166 | 0.659 | 0.006** |
| IP-10 | 0.154 | 0.491 | 0.584 | |
| MCP-1 | 0.014* | 0.167 | 0.501 | 0.024* |
| MIP-1β | 0.044* | 0.834 | 0.062 | 0.005** |
| VEGF-A | 0.018* | 0.517 | 0.712 | |
*p < 0.05, **p < 0.01, and ***p < 0.001.
IFNγ: interferon gamma, IL: interleukin, IL-36RA: IL-36 receptor antagonist, IP-10 (CXCL10): IFNγ inducible protein 10, MCP-1 (CCL2): monocyte chemoattractant protein-1, MIP-1β (CCL4): macrophage inflammatory protein-1 beta, VEFG-A: vascular endothelial growth factor A.