Table 1.

Association analyses between individual SNP and colorectal cancer risk in the three phases and combined samples

Stages		Asian/Chinese (n = 27,515)			European population (n = 76,614)
		Cases/Control	OR (95%CI)	P	Cases/Control	OR (95%CI)	P
Discovery stage (n = 49,209)
CC		458/603a	1		996/998b	1
Recessive (TT)		1960/3494a	0.89 (0.82–0.96)	1.90 × 10−3	11,633/13,430b	0.93 (0.89–0.97)	5.81 × 10−4
Additive model			0.88 (0.83–0.94)	2.69 × 10−5		0.94 (0.90–0.97)	2.45 × 10−4
Replication stage I (n = 10,444)
CC		274/228c	1		124/570d	1
Recessive (TT)		614/705c	0.74 (0.64–0.86)	1.02 × 10−4	577/3253d	0.78 (0.69–0.88)	1.33 × 10−4
Additive model			0.84 (0.75–0.92)	3.74 × 10−4		0.85 (0.78–0.94)	8.45 × 10−4
Replication stage II (n = 44,476)
CC		872/1633e	1		677/3065f	1
Recessive (TT)		1800/3611e	0.89 (0.83–0.96)	3.81 × 10−3	2152/11,317f	0.92 (0.86–0.97)	4.44 × 10−3
Additive model			0.94 (0.90–0.99)	1.76 × 10−2		0.93 (0.89–0.97)	1.01 × 10−3
Combined study (n = 104,129)
CC		1604/2464	1		1797/4633	1
Recessive (TT)		4374/7810	0.90 (0.86–0.95)	6.49 × 10−5	14,362/28,000	0.89 (0.84–0.94)	9.76 × 10−6
Additive model			0.91 (0.88–0.95)	2.92 × 10−7		0.92 (0.88–0.95)	4.61 × 10−6

^aChinese individuals collected from the Chinese Academy of Medical Sciences, Tongji Hospital of the Huazhong University of Science, and Technology, Zhongnan Hospital of Wuhan University, and Renmin Hospital of Wuhan University

^bEuropean individuals in GECCO

^cChinese individuals collected from Chinese Academy of Medical Sciences

^dEuropean individuals from PLCO

^eChinese individuals collected from Tongji Hospital of Huazhong University of Science and Technology

^fEuropean individuals from UKB. OR and 95%CI calculations were conducted under the assumption that variant alleles were risk alleles