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. Author manuscript; available in PMC: 2024 Jun 11.
Published in final edited form as: ACS Chem Biol. 2023 Mar 15;18(4):746–755. doi: 10.1021/acschembio.2c00680

Figure 4: Hydrophobicity enhances uptake.

Figure 4:

Relative fluorescence intensity of peptides with various hydrophobic groups compared to R9 and the reported peptide, CPP12. Each peptide was incubated with MDA-MB 231 cells at a concentration of 5 µM for 2 h. Error bars represent the standard deviation of three independent experiments. φ = 2-naphthylalanine, f = D-phenylalanine. * indicates significant difference from all other peptides except 2i, 5i, or R9 p<0.001. Split diamonds indicate differences from all other conditions p<0.01, 1-way ANOVA, Tukey.