Antiproliferative activity (GI₅₀ in μM) against human solid tumor cell lines of selected compounds (2 and 7)^a.

Comp.	A549	HBL-100	HeLa	SW1573	T-47D	WiDr
2a	47 ± 6.8	58 ± 12	49 ± 7.9	54 ± 10	53 ± 9.8	48 ± 13
2e	27 ± 4.8	34 ± 8.5	26 ± 3.3	28 ± 9.7	31 ± 8.4	31 ± 7.9
2f	37 ± 7.5	44 ± 9.8	39 ± 8.0	47 ± 18	35 ± 16	32 ± 12
2i	>100	>100	>100	>100	>100	>100
2k	>100	>100	48 ± 18	>100	>100	>100
2l	73 ± 34	77 ± 34	76 ± 36	>100	83 ± 35	>100
7a	>100	>100	75 ± 16	>100	>100	>100
7c	>100	>100	56 ± 18	>100	56 ± 21	48 ± 11
7d	>100	>100	>100	>100	>100	>100
7e	>100	>100	>100	>100	>100	>100
7f	>100	>100	43 ± 6.9	>100	79 ± 29	62 ± 0.4
7h	>100	>100	>100	>100	>100	>100
7ib	24 ± 10	24 ± 3.3	13 ± 4.2	15 ± 3.8	17 ± 6.1	21 ± 9.1
7jb	3.9 ± 0.3	8.6 ± 3.4	3.6 ± 0.2	4.4 ± 0.04	6.2 ± 0.4	6.8 ± 1.5
7k (CN)	82 ± 15	>100	43 ± 5.4	88 ± 14	67 ± 23	75 ± 32
CDDP	4.9 ± 0.6	1.9 ± 0.2	1.8 ± 0.5	2.7 ± 0.4	17 ± 3.3	23 ± 4.3
5-FU	2.2 ± 0.3	4.4 ± 0.7	19 ± 1.2	3.3 ± 1.2	8.2 ± 2.0	49 ± 6.7

^aFor all compounds, GI₅₀ values are given in μM and are means of two to four experiments (mean ± SD).

^bObtained by KO^tBu (3 equiv.), blue-LEDs in DMSO (ref. 76).