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. 2024 Jun 4;6(3):fcae194. doi: 10.1093/braincomms/fcae194

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Change in BOLD signal over time. Shown is the change in BOLD signal over time for the olfactory system in response to Veh (red line) and 100 µg/kg of LSD (blue line). Three hundred fifty images were acquired over the 35-min imaging session. Each acquisition is the mean ± Se of Veh and high-dose LSD rats combining the data from the three layers of the olfactory bulb, rostral and caudal piriform cortex and olfactory tubercles for all subjects for each experimental condition. The 1% threshold is highlighted by the red lines to account for the normal fluctuations in BOLD signal in the awake rat brain. A two-way ANOVA showed a significant time × treatment interaction, F = 4.424, P < 0.0001. IP, intraperitoneal.