Table 3.

Overview of sub-studies which have recruited PREVENT participants

Study name	Lead researcher	Study description
Linguistic markers of future risk for Alzheimer’s disease	Professor Alison Wray, University of Cardiff	Online assessment where language use was analysed to investigate whether linguistic markers could identify potential risk for future Alzheimer’s disease. A total, of 179 participants completed the baseline assessment, and 35 were followed up 2 years later to identify any changes in language use across this time period.
Approaches to the Communication of Alzheimer’s disease risk (ACAR study)	Dr Richard Milne, University of Cambridge	Focus groups held with research participants investigating attitudes to communication of future risk of dementia. Sixteen PREVENT participants were recruited alongside additional volunteers recruited from other research studies across Europe. The focus groups were structured to explore participants’ interest in learning about their Alzheimer’s disease risk and what their preferences were around disclosure.38
PREVENT-Elicitation of Dialogues (PREVENT-ED) study	Dr Sofia De La Fuente Garcia	Collected speech data from 43 participants enrolled at the Edinburgh site while they engaged in a cognitively stimulating task. Audio recordings were processed for speech features and machine learning methods used to test for associations between these features and risk factors collected in the PREVENT cohort.39
Mobile-technologies for the Assessment of Cognition (MTAC) study	Dr Ivan Koychev, University of Oxford	Thirty-five participants recruited from PREVENT Oxford site. Explored usability of a smartphone-based application to track cognition and function and positional technology using interactions between a smartwatch and Bluetooth beacons positioned around the homes to assess the level of function, activity and ability to navigate the environment.
Neureka	Dr Claire Gillan, Trinity College Dublin	Ninety-four PREVENT participants completed cognitive assessments via a mobile phone-based application to assess the validity of these tests in comparison with gold standard in person assessments.
Oral Health in PREVENT	Prof Angus Walls, University of Edinburgh	Pilot study was conducted at the Edinburgh and Dublin PREVENT sites investigating periodontal disease and future risk for dementia. Participants were invited for a dental examination including a dental X-ray and provided plaque and saliva samples.
Sunrise in PREVENT study	Prof Yves Dauvilliers, University of Montpellier	Participants were invited to wear a sleep activity recording device attached to their chin, which measures mandibular movements to monitor sleep behaviour and aid the diagnosis of obstructive sleep apnoea.
Barriers, facilitators and motivators to dementia prevention research	Dr Laura Booi, Leeds Beckett University	Aimed to explore what facilitates participation in dementia prevention research and what might be barriers. Recruitment was targeted to those from seldom heard groups in research to try and understand what challenges there might be to research participation. Interviews were conducted with 19 participants and analysed using thematic analysis.
Fear about memory loss in midlife	Dr Francesca Farina, Northwestern University, USA	Participants completed an online assessment exploring fear of memory loss in midlife. Various scales related to fear and avoidance were conducted by participants to understand the level of fear certain individuals may have about dementia while in midlife and whether this may impact their social behaviour.
Auditory Attention in Cognitive disorder (AudCog)	Dr Meher Lad, Newcastle University	Participants were invited to complete an online auditory assessment using multiple tasks to assess auditory function (pure-tone audiometry, speech-in noise perception task, auditory figure ground task, auditory working memory task and auditory sequence learning task).