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Schematic representation of FIV-PPR mutant profiles with cytotropism. A total of five mutations were noted between FIV-PPR and FIV-PPRchim42. The minimal requirement for growth on adherent cells was a specific triad of mutations, specifically, two within SU at positions 224 and 470 and the incorporation of a premature stop codon in TM at position 838. All of the mutants grew productively on the MCH5-4 T-cell line. LTR, long terminal repeat.
