FIG. 6.

Graphic representation of infections of IL-2-dependent cells (MCH5-4), IL-2-independent cells (MCH5-4DL), and an adherent glial cell line (G355-5) in the presence of SDF1α and RANTES. A 55% inhibition was observed when SDF1α was added to cultures of FIV-PPR-infected MCH5-4 cells. The inhibition by SDF1α was increased to 80% in cultures of FIV-PPR-infected MCH5-4DL cells. FIV-PPRchim42 infections were inhibited to a greater extent on MCH5-4 cells and to near equal levels to FIV-PPR inhibition on the MCH5-4DL cells in the presence of SDF1α. SDF1α inhibited FIV-34TF10 and FIV-PPRchim42 infections on G355-5 cells to nearly 100%. RANTES inhibited FIV-PPR infection by 30%, whereas there was no effect on FIV-PPRchim42 infection of MCH5-4 cells. RANTES was able to minimally inhibit FIV-PPRchim42 infection of the IL-2-independent MCH5-4DL cells; however, the most marked effect with RANTES was observed for the FIV-PPR infection of these cells, although the graph represents a percent inhibition of a low-level infection wherein the RT values were less than 25,000 cpm. RANTES had a very minimal to no effect on infections of G355-5 cells.