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. 2024 Apr 15;21(6):974–982. doi: 10.1038/s41592-024-02239-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Ensemble contacts maps of four cell lines at 1 Mb resolution, translocations are highlighted with red arrow. b, UMAP showing four represented markers for each cell type and one maker gene of G2M phase. c, Expression of top cell-type-specific marker genes for each cell type, top 20 of each cell type are shown. d, Mean scA/B value of cell-type-specific marker genes among single cells. For each cell types, the top 200 marker genes were identified from the paired transcriptome data. e, Scatter-plot showing the mitotic contact band (2–12 Mb) ratio versus short-range contacts (< 2 Mb) ratio. f, UMAP visualizing the mitotic band ratio of cell line embedding. g, Represented contact maps of cells in metaphase cluster. h, Pile-up of cell-type-specific chromatin loops using ensemble interaction profiles from each cell type. i, Heatmap showing the enrichment of cell-type-specific chromatin loops among single cells.