Figure 3.

CD4 T cell responses to SARS-CoV-2 proteins correlate

The abundance of cytokine producing CD4 cells reactive with the peptides encoded by the indicated classes of proteins as well as individual structural proteins or segments were analyzed for correlation coefficients. Using XY plots, the sum of the CD4 T cell IFN-γ response to the structural proteins (X axis) was plotted against the sum of the IFN-γ CD4 T cell response to the accessory proteins (A) and the non-structural proteins (B). In panel C the response to the nonstructural and accessory proteins are correlated. In panel D the CD4 T cell IFN-γ response to S1 was plotted against the response to S2 and in panels E and F the responses to NCP and Membrane, respectively, were evaluated against the response to spike. The r and p values shown in the left corner of each panel were calculated using the Spearman correlation.