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Families with known pathogenic variants defining hereditary cancer syndromes
(A) Family identified with BRCA2 c.573_574del variant. Pedigree supports a highly penetrant autosomal dominant pattern of inheritance.
(B) Family identified with TP53 c.586C>T variant. The variant is pathogenic and associated with LFS. Proband is an affected non-carrier. Cancer types: Br, breast; Kid, kidney; Leu, leukemia; Oth, unknown source; Ov, ovarian; Pan, pancreatic.
