Figure 5.

Family identified with multiple pathogenic VOUS(s) likely explained by LS

Family 084 carried a pathogenic MSH6 variant c.892C>T, a pathogenic CHEK2 c.1229del variant, and a missense CDH1 c.808T>G variant. While the MSH6 variant was likely transmitted through the proband’s maternal lineage, the CHEK2 and CDH1 variants were likely transmitted to individual III-1 from their married-in father. If more than one variant was identified, WT was written in the corresponding gene color. Cancer types: Br, breast; Leu, leukemia; Pro, prostate; Unk, unknown age.