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. 2024 Jun 11;15:4773. doi: 10.1038/s41467-024-48625-2

Fig. 2. Region-specific gene expression profile and cellular composition changes.

Fig. 2

a Volcano plot showing DEGs by ROI types—OE, IE, OD, and VA respectively; the number of DEGs were determined by cutoffs of adjusted p value < 0.1 and |log2FC| > 0.5 (using DESeq2 method), b UpSet plots comparing the intersections of region-specific DEGs, c Hallmark, non-germline gene set enrichment analysis across four ROI types; NES Normalized Enrichment Scores; Arrow indicates tissue locations, where OE is the outermost layer and VA is the innermost layer. Source data are provided as a Source Data file.