Fig. 5. Metabolic gene set enrichment analysis.

A Heatmap showing fold change differences (log2FC) between flight and ground control samples in oxidative phosphorylation pathway in both ST and multiomics datasets. There is a spaceflight-mediated inhibition seen for this pathway that is consistent across the two datasets. Two-sided Wilcoxon’s rank-sum test was done with FDR adjustment. B Heatmap showing fold change differences (log2FC) between flight and ground control samples in Arachidonic acid metabolism pathway in both ST and multiomics datasets. There is a deficit for this pathway seen in spaceflight samples in both the datasets. Two-sided Wilcoxon’s rank-sum test was done with FDR adjustment. C Heatmap showing fold change differences (log2FC) between flight and ground control samples in Fatty acid synthesis pathway in both ST and multiomics datasets. There is a spaceflight-mediated reduction observed for this pathway in both the modalities. Two-sided Wilcoxon’s rank-sum test was done with FDR adjustment. multiomics cl: multiomics cluster.