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. 2024 Jun 11;10:278. doi: 10.1038/s41420-024-02040-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Immunofluorescence study showing pRPA32(S33) foci in SKOV3 cells treated with DMSO, 5 nM prexasertib, 5 µM PDD and their combination. B Histogram representation of total cells positive for pRPA32(S33) foci in SKOV3 cells treated with DMSO, 5 nM prexasertib, 5 µM PDD and their combination. A total of 50 cells from each of the three different experiments were counted for our histogram. C Immunofluorescence study showing pH2AX(S139) foci in SKOV3 cells treated with DMSO, 5 nM prexasertib, 5 µM PDD and their combination. D Histogram representation of percentage of cells with total pan-nuclear pH2AX(S139) staining in SKOV3 cells treated with DMSO, 5 nM prexasertib, 5 µM PDD and their combination. A total of 50 cells from each of the three different experiments were counted for our histogram. Error bars represent the mean ± standard deviation in case of pRPA32(S33) foci and mean ± standard error of mean (SEM) in case of pH2AX(S139). One-way ANOVA using Tukey’s multiple comparison tests were performed to analyze the statistical significance. n.s. not significant; *p < 0.05; ****p < 0.0001.