Table 1.
Baseline characteristics of women with PCOS at inclusion, first trimester of pregnancy.
| Total (n=309) |
Metformin (n=153) | Placebo (n=156) |
|
|---|---|---|---|
| Age (years) | 29.3 ± 4.4 | 29.5 ± 4.4 | 29 ± 4.3 |
| Height (cm) | 167.5 ± 5.6 | 167.3 ± 5.8 | 167.7 ± 5.3 |
| Weight (kg) | 81.5 ± 19.5 | 83.5 ± 20.2 | 79.4 ± 18.5 |
| BMI (kg/m2) | 29.2 ± 7.2 | 29.8 ± 7.0 | 28.5 ± 7.4 |
| Systolic BP (mm Hg) | 118 ± 12 | 119 ± 12 | 117 ± 12 |
| Diastolic BP (mm Hg) | 73 ± 9 | 74 ± 9 | 72 ± 10 |
| Parity n (%) | |||
| P= 0 | 176 (57) | 89 (58) | 87 (56) |
| P≥ 1 | 133 (43) | 64 (42) | 69 (44) |
| Smoking n (%) | 22 (8) | 14 (10) | 8 (6) |
| Caucasian n (%) | 302 (98) | 147 (97) | 155 (99) |
| Gestational age at inclusion (days) | 72.7 ± 13.8 | 72.7 ± 14.0 | 72.8 ± 13.6 |
| Hypothyroidism prior to inclusion n (%) | 15 (5.6) | 7 (5.2) | 8 (5.9) |
| TPO-ab (+) n (%) | 20 (7) | 10 (7) | 10 (7) |
| PCOS phenotype | |||
| A (HA+OΑ+PCOM) n (%) | 161 (60) | 79 (59) | 82 (61) |
| B (HA+OΑ) n (%) | 11 (4) | 7 (5) | 4 (3) |
| C (HA+PCOM) n (%) | 27 (10) | 15 (11) | 12 (9) |
| D (OΑ+PCOM) n (%) | 71 (26) | 34 (25) | 37 (27) |
BMI, Body Mass Index; BP, blood pressure; TPO-ab, thyroid peroxidase antibodies; PCOS, polycystic ovary syndrome; HA, hyperandrogenism; OA, oligo-/anovulation; PCOM, polycystic ovarian morphology.
Continuous variables are presented as mean ± SD and categorical variables as number (%) of participants.
None of the comparisons between the groups showed statistically significant difference (p>0.05).