Table 2.

Standard deviations in birthweight, birth length and birth head circumference z scores per 1 mIU/L increase in TSH and 1 pmol/L increase in fT4.

Multivariable Associations Between Thyroid Function Parameters and Birthweight z Scores by Study Visit, adjusted for BMI
	Baseline (gw5–12)		Gw19		Gw32		Gw36
Hormones	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value
TSH	-0.01 (-0.14; 0.11)	0.827	-0.02 (-0.14; 0.10)	0.743	0.04 (-0.10; 0.17)	0.592	-0.02 (-0.17; 0.12)	0.753
fT4	-0.07 (-0.14; -0.00)	0.057	-0.05 (-0.13; 0.04)	0.271	-0.07 (-0.17; 0.02)	0.132	0.02 (-0.07; 0.11)	0.637
ΔTSH	0.03 (-0.12; 0.18) p=0.687
ΔfT4	0.10 (0.02; 0.18) p=0.017

Multivariable Associations Between Thyroid Function Parameters and Birth Length z Scores by Study Visit
	Baseline (gw5–12)		Gw19		Gw32		Gw36
Hormones	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value
TSH	-0.02 (-0.18; 0.13)	0.756	P -0.24 (-0.48; 0.00)	0.053	0.01 (-0.16; 0.17)	0.951	P -0.29 (-0.56; -0.03)	0.032
			M 0.08 (-0.16; 0.32) *1	0.497			M 0.10 (-0.11; 0.30) *2	0.36
fT4	-0.09 (-0.17; -0.00)	0.048	-0.02 (-0.12; 0.07)	0.651	-0.08 (-0.19; 0.03)	0.15	-0.04 (-0.13; 0.06)	0.45
ΔTSH	-0.05 (-0.19; 0.10) p=0.540
ΔfT4	0.10 (0.00; 0.19) p=0.047

Multivariable Associations Between Thyroid Function Parameters and Birth Head Circumference z Scores by Study Visit, adjusted for BMI
	Baseline (gw5–12)		Gw19		Gw32		Gw36
Hormones	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value	b (95% CI)	p value
TSH	-0.07 (-0.20; 0.06)	0.306	-0.01 (-0.13; 0.12)	0.893	0.04 (-0.11; 0.18)	0.608	-0.03 (-0.18; 0.11)	0.658
fT4	-0.03 (-0.10; 0.05)	0.436	-0.02 (-0.11; 0.06)	0.569	-0.02 (-0.12; 0.07)	0.626	0.04 (-0.06; 0.13)	0.439
ΔTSH	0.07 (-0.09; 0.22) p=0.380
ΔfT4	0.05 (-0.03; 0.13) p=0.227

P, placebo group.

M, metformin group.

*¹p value for interaction = 0.064.

*²p value for interaction = 0.024.

The bold values represent statistically significant results.