Table 3.

Associations between maternal TSH and fT4 and the outcomes LGA and SGA (OR per 1 mIU/L increase in TSH/ΔTSH and 1 pmol/L increase in fT4/ΔfT4).

Associations Between Maternal Thyroid Function Parameters and Odds of LGA Infant
	Baseline (gw5–12)		Gw19		Gw32		Gw36
Hormones	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
TSH	0.47 (0.26–0.85)	0.012	0.58 (0.35–0.98)	0.042	0.80 (0.47–1.36)	0.415	0.77 (0.48–1.24)	0.29
fT4	0.92 (0.73–1.17)	0.514	0.99 (0.77–1.28)	0.96	0.91 (0.67–1.25)	0.579	1.02 (0.77–1.34)	0.903
ΔTSH	1.99 (1.10–3.61), p=0.023
ΔfT4	1.25 (0.94–1.65), p=0.122

Associations Between Maternal Thyroid Function Parameters and Odds of SGA Infant
	Baseline (gw5–12)		Gw19		Gw32		Gw36
Hormones	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
TSH	P 0.93 (0.51–1.68)	0.811	0.70 (0.43–1.29)	0.142	0.86 (0.54–1.36)	0.516	0.85 (0.53–1.37)	0.507
	Μ 0.32 (0.14–0.71)*1	0.005
fT4	1.08 (0.90–1.29)	0.407	1.10 (0.87–1.39)	0.414	1.05 (0.80–1.39)	0.725	0.93 (0.71–1.23)	0.623
ΔTSH	1.28 (0.80–2.07), p=0.307
ΔfT4	P 1.02 (0.77–1.34), p=0.914
	M 0.58 (0.40–0.84), p=0.004 *2

*¹p value for interaction= 0.035.

*²p value for interaction= 0.024.

M, metformin group.

P, placebo group.

The bold values represent statistically significant results.