Table 4.

Anthropometrics at birth of offspring born to mothers with PCOS exposed to metformin (n=153) or placebo (n=156).

Variable	(n)	Total	(n)	Metformin	(n)	Placebo	p-value
Gestational age (weeks)	309	39.1 ± 2.0	153	39.3 ± 1.6	156	38.9 ± 2.3	0.533
Weight
grams	309	3529 ± 600	153	3555 ± 551	156	3504 ± 647	0.455
z-score	309	-0.05 (-0.17; 0.06)	153	-0.10 (-0.27; 0.08)	156	-0.01 (-0.17; 0.14)	0.474
Length
cm	305	50 ± 3	152	50 ± 2	153	50 ± 3	0.901
z-score	305	-0.52 (-0.66; -0.38)	152	-0.63 (-0.83; -0.44)	153	-0.41(-0.60; -0.22)	0.101
Head circumference
cm	306	35 ± 2	152	36 ± 2	154	35 ± 2	0.003
z-score	306	0.19 (0.06; 0.31)	152	0.31 (0.13; 0.49)	154	0.06 (-0.10; 0.22)	0.043
SGA n (%)		37 (12)		20 (13)		17 (11)	0.556
LGA n (%)		33 (11)		17 (11)		16 (10)	0.808

Values expressed with a plus/minus sign are the mean ± standard deviation.

Values in parentheses are 95% CIs.

Students t- test was performed. T-test with separate variance estimates was used for birthweight in grams because of non-homogenous variances.

SGA (small for gestational age): weight z-score< -1.28.

LGA (large for gestational age): weight z-score >1.28.

The bold values represent statistically significant results.