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. 2024 May 29;15:1377817. doi: 10.3389/fimmu.2024.1377817

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Copyright © 2024 Xu, Tao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional regulatory network of neutrophils. (A) UMAP plot depicts the distribution of neutrophils in the sepsis and healthy control groups. (B) Activity distribution of FOS, REL, JUN, FOSB, and JUND. (C) Heatmap shows the differences of TFs in neutrophils between the sepsis and healthy control groups. (D) Heatmap of the top 25 regulators with the highest area under curve (AUC) scores showing the activity of TFs in neutrophils clusters using SCENIC. (E) Top activities of TFs between different groups. RSS indicates Regulon Specificity Score. (F) Correlation between eight hub genes (ALPL, ACTB, CD177, GAPDH, SLC25A37, S100A8, S100A9, and STXBP2) expression and the level of 24 inferred TFs. *, P<0.05; **, P<0.01; ***, P<0.001.