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DexS inhibition of MAb binding to gp120
| Epitope | MAb | Fold reduction in half-maximal MAb binding to gp120 ofa:
|
|
|---|---|---|---|
| IIIB (X4) | JRFL (R5) | ||
| V2 | G3-136 | 1.0 | NBb |
| SC258 | 1.0 | 1.0 | |
| C108G | 8.6 | NB | |
| V3 | 9284 | 5.0 | NB |
| 110.I | 100 | NB | |
| 50-23 | 1.2 | NB | |
| Loop2 | NB | 3.0 | |
| 19b | NB | 1.4 | |
| 447-52D | NB | 1.1 | |
| CD4bs | IgG1b12 | 1.9 | 1.5 |
| 21h | 1.0 | 1.0 | |
| CD4i | 17b | 50.0 | 1.8 |
| 48d | 37.0 | 2.4 | |
| Other | 2G12 | 1.0 | 1.5 |
Inhibition studies were performed in the presence of 12.3 μM DexS.
NB, no significant MAb binding to gp120 species.
